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Adverse Events, Side Effects, and Safety Considerations Overall, GLP-1 RAs are very well tolerated considering their high efficacy in controlling glycemia and the net effect they exert on multiple organ systems (Fig

This slight modification significantly impacts where and how each compound can be utilized within the body

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For patients with diabetes who also have obesity or elevated cardiovascular risk, GLP-1 therapy may offer an added advantage rather than a standalone solution

Together they produce a larger, synergistic GH pulse than either alone