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The dosage can be increased to 420 mg every 2 weeks if a clinically meaningful response is not achieved in 12 weeks

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After reverse transcription, reagents and sample cDNA were added according to PCR reaction system and performed on LightCycler 96 system (Roche Diagnostics, Mannheim, Germany)

2 Mechanisms of action and ongoing therapeutic innovations in GLP-1 receptor agonists All GLP-1 RAs mimic the endogenous hormone GLP-1, binding to GLP-1 receptors (GLP-1 Rs) distributed in pancreatic islets, the gastrointestinal tract, and the brain