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Its injected under the skin weekly and is paired with exercise and a modified diet to help manage weight
Los autores concluyeron que el orforgliprn representa una "posible nueva opcin teraputica" para personas con DT2 que consideran iniciar la terapia con ARS GLP-1 y que podran "preferir una alternativa a la va subcutnea de administracin." Michael Nauck, MD, jefe de investigacin clnica de la Divisin de Diabetes, Departamento Mdico I, Hospital Josef, Universidad Ruhr de Bochum, Alemania, calific el estudio de "importante" porque permite comparar "los RA GLP-1 competidores diseados para administracin oral, en cuanto a eficacia y tolerabilidad." Nauck, coautor de un editorial adjunto , 2 considera que las diferencias entre orforglipron y semaglutida es decir, mejor eficacia pero mayor riesgo de eventos adversos gastrointestinales sugieren un uso diferenciado para quienes necesitan mejoras sustanciales en el control glucmico, frente a dar prioridad a una buena tolerabilidad
WEGOVY (semaglutide) injection 2.4 mg is an injectable prescription medicine used with a reduced calorie diet and increased physical activity: to reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight
Step 1: Do not inject This is not the time for "it is probably fine" thinking
The concept, described by the authors as computational social listening, has relied on the ability of these models to interpret highly variable patient language and align it with clinically recognised terminology
Patients with T2D and CKD should be treated with a sodium-glucose cotransporter-2 inhibitor and, if necessary, additional pharmacological treatment should be introduced to improve glycemic control (1B)
