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Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4 methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain
However, these issues can sometimes be circumvented, for example through N -alkylation, 8 inclusion of D-amino acids or use of disulfide, ring closing metathesis (RCM) or lactam formation as cyclisation approaches
The capsules are small and easy to take, with no unpleasant aftertaste or smell, which is a big plus compared to some other acetyl-l-carnitine supplements
Rodent toxicity studies from the Sikiric group have not identified significant acute toxicity
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