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2.6 Software Datasets containing PK and covariate data from each trial were converted to a format compatible with the modelling software NONMEM (ICON Development Solutions, Ellicott City, MD, USA), Version 7.3

10.1002/glia.21091 31

GHK-Cu drives collagen production through activation of transforming growth factor-beta (TGF-) signaling, the most potent endogenous stimulator of collagen synthesis in fibroblasts