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Brains were cut into 30-m coronal sections on a cryostat (Leica microsystem) and stored in cryoprotectant until processing for immunohistochemistry

Mitophagy constitutes a critical adaptive survival mechanism for tumor cells under therapeutic pressure by eliminating treatment-induced damaged mitochondria, limiting reactive oxygen species accumulation, and maintaining mitochondrial homeostasis, thereby providing a buffering capacity for the development of resistance

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