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While copper is an essential trace mineral, it is not benign in excess
Since increased glycolysis, particularly in the context of impaired electron transport, increases the ratio of NADH to NAD +, excess NADH is thought to directly promote postischemic inflammation
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The amount of glutathione in the sample may be low
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Conclusion: NTZ exerted a hepatoprotective effect in MTX-challenged rats that is mediated via modulation of ER stress and inhibiting apoptosis
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