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Why the escalation schedule exists Early clinical development tested faster escalation schedules

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Ipamorelin: This is a selective pentapeptide that acts as a ghrelin receptor agonist

Gastroenterology 146 , 652660 (2014)

Conversely, while the metabolic burden in the reproductive subtype is relatively lighter, ovulatory dysfunction and hyperandrogenic symptoms are more prominent, suggesting that the mode of benefit may differ in these patients (51, 54)