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Although the overall structures of retatrutide-bound GLP-1R, GIPR and GCGR are highly similar, with C root mean square deviation (RMSD) values of 0.880.93 , unique structural features were noted at ECL1, ECL3 and the extracellular tips of TM1, TM3 and TM7, displaying receptor-specific positions and conformations

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The precipitate is washed twice, dissolved in 3.0 mL of bidistilled water, 1 mL of a 0.85% aqueous solution of TBA is added, dissolved in 25 mL of acetic acid with the addition of 5 mL of H2O

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