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Moreover, not all methodologies utilized in these studies are properly validated against the gold standard, i.e., the Ussing chamber, and therefore caution is needed in the interpretation of these permeability data

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At the same time, the drug development horizon is full of promising directions: oral formulations, multi-agonists, longer-acting molecules, and the emergence of biomarkers to personalize therapy

doi: 10.1074/jbc.M109.067207 98 KoehlerJADruckerDJ