Clues from a two-step mendelian randomized study
The issue of obesity and insulin resistance prompted the design of a number of studies investigating the effects of antidiabetic drugs in PCOS, as reported in recent and very exhaustive reviews on the available clinical trials on glucagon-like peptide 1 receptor agonists (GLP-1RA) in PCOS [21, 23, 24]
Moderation is the practical answer here
Broderick, Midwestern University, United States Updates Copyright 2021 Li and Zhao
Longer-term safety questions including effects on the pancreas, thyroid, gallbladder, and cardiovascular system remain under investigation in ongoing Phase 3 trials
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