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The GH Research Society recommends that IGF-1 levels during any GH-stimulating therapy remain within the age-normalized reference range to minimize overstimulation risk [9]
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After diabetes confirmation, the animals were assessed for hyperalgesia (using the hot plate and tail immersion tests) during weeks 1, 2, 3, 4, 5, and 6 to confirm the presence of diabetic neuropathy, following a protocol adapted from Gong et al
Klusmann, J.-H
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