Pharmacol Biochem Behav 46 : 423426 Moreau JL, Jenck F, Martin JR, Mortas P, Haefely WE
As a key commensal bacterium for maintaining gut barrier integrity, the reduction of Akkermansia may exacerbate hyperandrogenemia and ovulatory dysfunction in PCOS by increasing LPS translocation, triggering ovarian macrophage pyroptosis and interferon- (IFN-)-mediated inflammatory responses, thereby disrupting steroid hormone synthesis, promoting granulosa cell apoptosis, and exacerbating hyperandrogenemia and ovulatory dysfunction in PCOS
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In addition, SA--gal highly expressed, together with elevated expression of p53 and progerin in cell nuclei in the CCl 4 group and the CCl 4 + LV-CTR group on Day 6 and Day 28