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A broad panel of antibodies was employed, including those for FOXO4, p53, phospho-p53, p21, p16, cleaved-Caspase3, BAX, BCL-2, testosterone synthesis enzymes (3-HSD, CYP11A1, CYP17A1), and various SASP factors (IL-1, IL-6, TNF-, TGF-)
Int J Immunopharmacol
For long-term daily use, most experts recommend staying within the 250 mg to 1,000 mg range to avoid potential mineral imbalances or digestive strain
Comparison of antioxidative and antifibrotic effects of alpha-tocopherol with those of tocotrienol-rich fraction in a rat model of chronic pancreatitis
Additionally, these biomolecules face issues such as off-target effects and difficulty in crossing biological membrane barriers, which to a certain extent hinder the exertion of drug efficacy (328, 329)
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