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Behaviorally, the LAC treatment during the last part of chronic restraint stress (CRS) enhanced resilience and reversed the effect of CRS, which is shown by increased social interaction and reduced passive behavior in a forced swim test ( Disorders of metabotropic glutamate (mGlu) receptors and neurotrophins have significant negative effects on neuroplasticity, leading to depression, but LAC regulate brain type 2 metabotropic glutamate (mGlu2) receptors and N-methyl-D-aspartic acid (NMDA) receptors to induce antidepressant effect ( Neurotrophic factors are associated with the pathogenesis of depression ( Oxidative Stress LAC promoted the removal of oxidation products and provided acetyl groups to regulate the expression of neuro-nutrients and glutamate genes ( cystine/glutamate antiporter) is an important component of antioxidant activity in vivo , which is associated with glutathione synthesis ( Neurotransmitter Regulation The neurotransmitters associated with depression mainly include monoamine, 5-methyl-hydroxytryptamine, and dopamine (DA) ( 1A antagonist, could significantly inhibit the antidepressant effects of acetyl-L-carnitine
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Efficacy and safety of once-weekly semaglutide 2.4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial
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