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In viral myocarditis caused by CVB3, macrophages are enriched in cardiac tissue as early as the third day post infection (239), and they secrete high levels of IL-1, which triggers the upregulation of NLRP3 in macrophages, potentially polarizing them to the M1 phenotype (240, 241)

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88 The central strategy for overcoming resistance to immunotherapy is to achieve synergistic efficacy through combination regimens, which primarily follow two directions: first, combining immune checkpoint inhibitors with other immunotherapies to activate the immune system at multiple levels

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