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A conditioned-taste aversion (CTA) experiment in male chow-fed Wistar rats affirmed a potent weight loss in response to GLP-1, semaglutide and GLP-1MK-801 compared with MK-801 and vehicle treatment
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In June 2023, Lilly reported that Orforglipron led to an average weight loss of up to 14.7% over 36 weeks in adults with obesity or overweight based on Phase II trial results
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