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However, it never received FDA approval because the results, while positive, weren't dramatic enough to meet regulatory thresholds for an obesity drug

(278) studied 14 healthy controls and 141 CKD patients, demonstrating that while plasma levels of protein-bound uremic toxins increased with CKD progression, fecal concentrations of these toxins and their precursors remained stable

Use of RNA interference to investigate gene function in the human filarial nematode parasite Brugia malayi

32 , S111115 (1992)

Stronger immunity

The largest efficacy study was unsuccessful Peer-reviewed obesity reviews report that the 24-week trial did not show enough weight loss compared with placebo