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March 2, 2025

The treatment schedule may involve various escalating doses, with the average weight loss results being visible typically after 4-6 weeks

3.1.1 Modulation of SSTR expression in vitro in NET cell lines Successful stimulation of SSTR2 through attenuation of methylation has been demonstrated in BON-1 cells by treatment with DNMTis 5-aza-2-deoxycytidine (5-AZA-dC) or 5-azacitidine (5-AZA), as shown by significantly enhanced uptake of [ 68 Ga]Ga-DOTA-TOC [57]

Pulsatile dosing: Some experiment with dose cycling (e.g., one month on, one month off) to minimize tolerance development

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