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Int J Oncol (2003) 23(5):131722
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Under conditions of reduced portal insulin-to-glucagon ratio, lipolysis increases in adipose tissue and releases non-esterifed fatty acids which are converted to ketone bodies in the liver through mitochondrial beta oxidation and ketogenesis [25], resulting in a metabolic condition resembling a prolonged fast [26]
Our central scenario reflected our current best-estimate assumptions for these indications, including expectations around future gains in efficacy, reductions in cost, and broader accessibility
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