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While both drugs appear to be safe for at least two years, questions remain about how they affect metabolism, organ health, and weight maintenance over many years

It is a single GLP-1 receptor agonist with an extensive clinical track record

Monitoring the pipeline for alternatives

The Aib and D-amino-acid residues confer protease resistance relative to native ghrelin-derived sequences

As a result, longer-term statements, including full weight regain within two years, rely on extrapolation beyond the available data, she said in a statement shared with CNN by the Science Media Centre, meaning that comparisons with behavioral changes should be interpreted as suggestive rather than definitive. In real-world terms, the findings reinforce that obesity management typically requires long-term planning

Human pituitary growth hormone