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This can most commonly be seen in polycystic ovarian syndrome (PCOS) or endometriosis

Guide for the Care and Use of Laboratory Animals, 8th Edition

Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible

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Its an investigational compound