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Therefore, interfering with lactate production or blocking its signaling pathway may become an effective strategy to inhibit abnormal tumor vascular development and distal metastasis (Fig

doi: 10.3389/fbioe.2020.00359 Received 17 February 2020 Accepted 31 March 2020 Published 30 April 2020 Volume 8 - 2020 Edited by Roberto Narcisi, Erasmus University Rotterdam, Netherlands Reviewed by Guus van den Akker, Maastricht University, Netherlands

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FDA advisory committees and review divisions retain authority to question whether trial populations, wherever they were enrolled globally, support a claim about a US patient population, and sponsors running geographically concentrated trials outside the United States should expect that scrutiny to continue regardless of the DAP guidance's administrative status