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And: It primarily affected people with a specific anatomical peculiarity of the optic nerve head, a so-called Crowded Disc . A Crowded Disc refers to a congenital anatomical configuration of the optic nerve head (papilla) where the opening in the eyeball through which the optic nerve exits the eye is very narrow relative to the thickness of the optic nerve

This is why many clinicians emphasize the importance of hydration and fiber when taking these medications

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GLP-1Rs are not only widely expressed in the central nervous system but also in peripheral nerves such as vagal afferents

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