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Gut/GI protection Explored in preclinical research on protection of the gastrointestinal tract, reflecting its origin in a protein found in gastric juice
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High-ROS environments can degrade the peptide, which is relevant in oxidative stress model experiments
Moreover, although the surface of HGF II-K1 for c-MET binding is exposed, the binding of another c-MET to HGF II-K1 in such rigid conformation would clash with HGF I bound c-MET II on the stalk region, explaining why rigid HGF II in the 2:2 complex cannot recruit additional c-MET molecule