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Lancet 351 : 13931396 Heron-Milhavet L, LeRoith D (2002) Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage
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Its just that SGTL2 inhibitors seem to tick many boxes, with, apparently, very low risk (at the very least for non-diabetic men at very low risk of UTIs and DKA): Geroscience-guided repurposing of FDA-approved drugs to target aging: A proposed process and prioritization 2022 image20001833 219 KB In mode details, Perspectives in weight control in diabetes SGLT2 inhibitors and GLP-1glucagon dual agonism 2023 image19201188 133 KB On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects
Interestingly, these markers largely reversed in liver-specific Gclc-Nrf2 DKO mice
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