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In vitro, H 2 O 2 caused abnormal accumulation of progerin in nuclear and activation of nuclear p53progerin interaction to trigger primary rat hepatocyte premature senescence through the p21-independent pathway
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Target cells were incubated with virus-containing medium and 2 g/mL polybrene (Sigma Aldrich) for 24 h, and then allowed recovery for 24 h prior to selection for transductants
Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation
The treatment group also showed significantly lower mortality compared to controls
No deaths
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