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Negative experiences The complaints paint a different picture, and they cluster around several recurring issues

High glucose levels lead to the creation of advanced glycation end products (AGEs), which contribute to fibrotic tissue formation [28], and both AGEs and excess insulin can promote fibroblast proliferation and ECM production [29,30]

again, oxidative stress is believed to be the culprit, with decreased GSTO gene expression resulting in a lowered age of onset for the diseases

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Given the heterogeneity of study designs and outcomes, results were synthesized using a narrative approach

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