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The molecule was first identified and studied by the Sikiric research group in Croatia starting in the early 1990s, and the bulk of the preclinical evidence base comes from more than three decades of rat and rodent studies showing consistent tissue-repair, anti-inflammatory, and gastroprotective effects

PRKN deficiency causes impaired mitochondrial autophagy leading to the release of mtDNA, which triggers inflammation

Current evidence does not support permanent hair follicle damage from these medications

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Immunocompromised patients should consult their healthcare provider before taking probiotics

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