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Some practitioners theorize that IV administration might provide advantages for certain applications, though clinical evidence supporting superiority of IV over IM administration for most wellness purposes remains limited

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Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp

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An RCT of 174 patients with severe alcoholic hepatitis found that the combination of prednisolone + NAC (IV for 5 days, then oral for 2 weeks) significantly reduced 1-month mortality compared to prednisolone alone (8% vs 24%, p=0.006), though the difference was not significant at 6 months (Nguyen-Khac et al., N Engl J Med, 2011) [36]