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For patients with severe kidney disease, impaired renal function can affect how excess B12 is cleared from the body
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NICE guidance recommends 1 mg hydroxocobalamin three times weekly for 2 weeks for patients without neurological symptoms, with lifelong maintenance therapy for irreversible causes
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Su L, Zhang J, Gomez H, Kellum JA, Peng Z (2023) Mitochondria ROS and mitophagy in acute kidney injury
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