injection site reaction glp 1 New Analysis Clarifies the Dermatologic Risks of GLP-1 RA Therapy Shedding Light on Injection-site Reactions

J Diabetes Invest 15(11):15661577 Yamada Y, et al (2020) Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial

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However, their financial sustainability remains an open question as utilization continues to rise, placing substantial strain on employer-sponsored health plans

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It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM (42)], but this now seems not to be the case