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Nature 468 , 664668 (2010)

Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells

1921 Recently, a double-blind, placebo-controlled randomized clinical trial of phase I study of (in)GSH in PD ( n =30) demonstrated (in)GSH was safe and tolerable, and both active study arms demonstrated an improvement over placebo in total Unified PD Rating Scale scores, specifically in activities of daily living and motor Unified PD Rating Scale subscores

Mechanistically, much of BPC-157s activity is attributed to angiogenesis and modulation of the nitric oxide (NO) system, as reviewed by Sikiric et al