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SOUL was a randomized, double blind, parallel-group, placebo-controlled superiority trial that enrolled 9,650 adults with T2DM who had established atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), or both, to receive a maximum daily dose of 14 mg oral semaglutide or placebo

Phentermine is contraindicated in hyperthyroid patients because sympathomimetic stimulation compounds the already elevated metabolic state

Strategies under investigation include the development of universal hypoimmunogenic hPSCs, which trigger a weaker immune response

Short-term GH pulses and higher IGF-1 can enhance glucose uptake in muscle and fat, reduce fasting insulin requirements, and redirect substrate utilization toward improved metabolic flexibility

Semaglutide is a GLP-1 receptor agonist initially developed to help regulate blood sugar levels in people with type 2 diabetes