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GLP-1 RAs may also improve liver function, this effect is thought to involve activation of AMP-activated protein kinase (AMPK), a key metabolic regulator that inhibits fatty acid synthesis and promotes fatty acid -oxidation, leading to decreased lipid accumulation in hepatocytes 22,23,24,25

Muscle Preservation During Weight Loss (Future)# Recommendation : Bioglutide Reason : Bioglutide's IGF-1 receptor activation may preserve muscle mass during weight loss, addressing a key limitation of all current GLP-1 therapies

Most clinical guidelines and obesity specialists recommend GLP-1 medications as long-term or indefinite treatments for obesity similar to how blood pressure or cholesterol medications are used chronically

The resulting weight lossoften 15-20% of body weight with higher doses approved for obesity (Wegovy/Zepbound) and 5-10% with lower doses for diabetes (Ozempic/Mounjaro)can actually improve several cardiovascular risk factors

Dosing The dose of semaglutide will be different for different patients