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IL-4 secreted by activated T cells has anti-angiogenic effects by inhibiting VEGF production in RA FLS, which helps relieve RA ( + T cells population ( via activation of protein kinase C (PKC) / II and ERK-1/2, with concomitant down-regulation of the NF-B/p65 pathway ( via activating Smad-2/3 in RA ( ( Figure 1 )
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While rodent studies suggest that BPC 157 interacts with tight junctions to decrease intestinal permeability, we lack any validated human data confirming this effect
Oral BPC-157 Dosing Protocols in Physician-Supervised Practice Typical dose: 250 to 500 mcg per day in one or two divided doses
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2020 Jun;141(6):492-509
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