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It is extrapolated from animal data and community experimentation, not from a human dose-finding trial
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doi:10.1056/NEJMoa1200111 Mingrone G, Panunzi S, De Gaetano A, et al
Using a long-term HFD-fed mouse model of NAFLD, we demonstrated in this study that NAFLD development occurs concomitantly with dysregulated hepatic glutathione homeostasis characterized by decreased GSH and increased GSSG, and increased TNF protein levels in both the circulation and the liver
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