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These medications have an overall positive safety profile
These medicines often produce much larger average weight loss in human clinical trials and are intended for medically supervised weight management
According to the FDA prescribing information for Zepbound, the most common gastrointestinal adverse reactions in the SURMOUNT clinical trials included nausea (24-30%), diarrhea (18-24%), vomiting (8-12%), constipation (16-17%), dyspepsia (5-9%), and abdominal pain (6-10%), with rates varying by dose
Am J Physiol Regul Integr Comp Physiol (2014) 306(5):R35262.10.1152/ajpregu.00491.2013 74 JimenezAMariACasamitjanaRLacyAFerranniniEVidalJ
Recent clinical trials, including a new head-to-head study, have further corroborated these findings, confirming that Tirzepatide leads to more significant reductions in body mass on average than Semaglutide
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