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Most of these studies have a combined predefined endpoint of the classical MACE-3 (major adverse cardiovascular endpoint) consisting of cardiovascular death, non-fatal myocardial infarct and non-fatal stroke

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Among commercially insured non-diabetic individuals with obesity, people who identified as female, received point-of-service or preferred provider organization insurance coverage, and who took medications such as antidepressants or thyroid or hormone medications, were more likely to begin taking semaglutide compared to people who identified as males, or those who were covered by health management organization or exclusive provider organization plans

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