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For gastrointestinal side effects , the following approaches are generally recommended: Gradual dose escalation : Starting at a low dose and increasing slowly over several weeks significantly reduces the severity of nausea and vomiting Dietary adjustments : Eating smaller, more frequent meals and avoiding high-fat or spicy foods can help manage nausea Hydration : Maintaining adequate fluid intake is important, particularly if diarrhoea or vomiting occurs, to reduce the risk of dehydration and acute kidney injury Temporary dose reduction or pause : If side effects are intolerable, pausing dose escalation or reducing the dose may be appropriate however, any change to dosing must only be made under the direction of the supervising clinician or in accordance with the trial protocol
Larche, M
Cell 184 , 615627.e7 (2021)
Additionally, patients experiencing significant side effects may stop taking their GLP-1 sooner than someone who doesnt experience side effects
Based on data from the Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023, the timeline for seeing meaningful results with retatrutide generally follows a predictable pattern, though individual responses vary considerably depending on dose, titration schedule, and personal factors
Molecules 25 (17), 3847
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