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The Copenhagen trial measured circulating biomarkers but did not perform tissue biopsies, so we don't know whether NNMT suppression in non-adipose tissues produces structural or functional changes over time

Rajagopalan, S., Andreeva, A., Rutherford, T

Engages FOXO transcription factor signaling networks: FOXO transcription factors regulate oxidative stress resistance, metabolic adaptation, and longevity-associated gene expression

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