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This structural modification documented in a 2020 Endocrine Reviews study enhances the peptides stability against dipeptidyl peptidase IV (DPP-IV) degradation, extending its half-life and producing a more sustained GH-releasing effect

Some large database analyses have suggested a modest increase in pancreatitis risk, particularly in the first few months after initiation, while others have found no association after adjusting for confounding factors such as obesity, gallbladder disease, and alcohol use

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Lau J, Bloch P, Schffer L, Pettersson I, Spetzler J, Kofoed J, et al

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