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Even TfR, the most widely and successfully investigated target for receptor-mediated brain drug delivery, is present throughout the body [8, 19, 20]

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Neuron, 102 (1), 48-59

What patients typically describe is a gradual sharpening over the first 2 to 4 weeks: less brain fog, easier recall, faster processing of new information, and a sense that complex tasks feel more manageable

Rebooting this cycle is demanding