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Our study implicates that targeting the estrogen-dependent system x c , specifically SLC7A11 and SLC3A2, with IKE through induction of ferroptosis in ER+ breast cancer cells, should offer a new therapeutic option for patients with ER+ breast cancer, particularly those with endocrine resistance

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24 HattoriN.HayashiT.NakachiK.IchikawaH.GotoC.TokudomeY.et al (2009)