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For instance, IGF-1 is made in the liver, hence an undiagnosed precancerous liver disease could have prevented the liver from producing normal levels of IGF-1. The study demonstrates the power of using population-level approaches to assess the extent to which risk factors apply across the entire cancer spectrum
Others may not have a significant impact
IGF-I, it appears, could be a potent growth-promoting hormone that hypothetically mediates several of the growth and anabolic action of growth hormone
10.1016/S0022-2143(02)00022-7 J
The first step of the mechanism involves formation of an "acyl-phosphate intermediate"
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