The standard titration schedule accommodates this adjustment
These side effects usually go away on their own within a few days to weeks
The compound was first reported in Al-Obeidi, Castrucci, Hadley, and Hruby, J Med Chem 32 (12):255561 (1989) (PMID 2555512), building on the earlier open-chain superpotent precursor [Nle, D-Phe]--MSH reported by Sawyer, Sanfilippo, Hruby, Engel, Heward, Burnett, and Hadley in PNAS 77 (10):57548 (1980) (PMID 6777774)
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Murphy H, Scott EM (2024) Demarcating the benefits of hybrid closed loop therapy in pregnant women with type 1 diabetes