In addition, treatment with folinic acid has shown results in autism spectrum individuals, by improving core behavioral deficits, and may minimize DNA uracil and homocysteine accumulation, which can avoid chromosome breaks, and, therefore, brain damage and cerebrovascular diseases (4, 20, 69)
In the context of acquired resistance, PDX models can be subjected to repeated drug exposure to mimic disease progression observed in patients transitioning from initial sensitivity to resistance
Meng Q, Li J, Wang C, Shan A
Houston EJ, Templeman NM
The implications include altered metabolism of several biomolecules and enzyme systems of well-established pathophysiologic relevance such as vitamins B6, B9 (folate), B12, D3, NO, lipids, amino acids, proteins, DNA, cytochrome P-450 and other enzyme systems, HO, and homocysteine
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