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For many individuals, this means reducing frequency from twice or three times weekly to once weekly, or adjusting doses downward while monitoring for any reduction in therapeutic benefits

Anti-myc ChIP assays revealed that the RRM1 + 2 variant failed to localize to R-looprich regions, including telomeres, -satellite, SatIII, SatII, and AluS sequences (Fig

HDTVI Hydrodynamic tail vein injection (HDTVI) was performed to deliver transposon-based vectors as previously described with minor modifications 53

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2.6 Preparation of aortic tissue After euthanizing mice from different groups using gas anesthesia, the thoracic aorta was surgically excised