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Mice lacking this gene showed signs of premature aging (shorter lifespan, osteoporosis, vascular calcification, skin atrophy)

Careful screening for personal and familial risk factors for thromboembolism is recommended before initiation.[] The drug is contraindicated in the presence of coagulation disorders, pregnancy and lactation to avoid any catastrophe,[] although potentially life threatening side effects namely deep vein thrombosis, pulmonary embolism and myocardial infarction have not been reported at this low dose.[] However, a variable relapse rate ranging from 9 to 27% has been reported after stopping the medication.[] Glutathione Glutathione, a low molecular weight thiol-peptide plays an important role in maintaining the intracellular redox balance, itself being a powerful antioxidant

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Sneeboer et al., 2019), all of which represent urgent clinical targets for intervention