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The International Olympic Committee has approved l-carnitine administration for its use as an ergogenic supplement because it causes little to no side effects
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These challenges include degradation by cellular nucleases, high renal clearance, and low penetration in biological membranes due to their negative charge
Quinlan et al., 2013), complex I and complex III (Venditti et al., 2013) have been shown to be the most important sources of mitochondrial superoxide generation, although significant production of ROS in complex II has recently also been reported (Quinlan et al., 2012)
Synchronous targeted delivery of TGF- siRNA to stromal and tumor cells elicits robust antitumor immunity against triple-negative breast cancer by comprehensively remodeling the tumor microenvironment
262 It functions not only in peripheral tissues but also directly within the CNS, crossing the blood-brain barrier or being produced centrally to act on the brain
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